- December 7, attack on Pearl Harbor triggers America's entrance into WWII. More than 2,500 men and 80 women serve in the nation's armed forces.
- New Broadway Street bridge over the Red Cedar River dedicated.
- Lakeside Aluminum Company becomes subsidiary of National Pressure Cooker Co. of Eau Claire.
- Co-op soybean reduction plant built.
- Verne C. Fryklund becomes president of Stout Institute.
- Menomonie Housing Authority established to provide homes for returning veterans.
- Menomonie celebrates its Centennial.
- Lange Canning Company moves to north Menomonie, establishes plant on Tainter Street.
- Sanna Dairies purchased by Nestle Food Company.
- Major addition and new entrance erected on hospital's east side.
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